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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEXDC
All Species:
7.27
Human Site:
S346
Identified Species:
20
UniProt:
Q8WVB3
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WVB3
NP_775891.2
486
53790
S346
E
N
L
L
G
I
S
S
L
E
K
T
D
P
V
Chimpanzee
Pan troglodytes
XP_001168179
478
52974
S338
E
N
L
L
G
I
S
S
L
E
I
T
D
P
V
Rhesus Macaque
Macaca mulatta
XP_001113324
484
53736
N338
E
N
L
L
G
I
S
N
L
E
M
M
D
P
V
Dog
Lupus familis
XP_548801
483
54151
N348
E
N
F
L
G
I
S
N
L
E
T
T
D
F
T
Cat
Felis silvestris
Mouse
Mus musculus
Q3U4H6
486
54558
S346
E
R
F
L
G
V
S
S
L
E
I
A
D
T
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513183
473
53276
E326
R
P
P
G
G
Y
S
E
K
V
K
D
V
A
G
Chicken
Gallus gallus
XP_001234313
499
57110
A363
S
W
L
R
V
R
E
A
M
P
R
F
A
P
L
Frog
Xenopus laevis
NP_001086776
379
43097
K247
D
Q
V
I
E
Q
V
K
S
F
L
G
M
T
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623705
485
55983
M351
V
A
K
C
L
G
Y
M
D
H
P
L
H
I
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.3
92.3
77.1
N.A.
78.8
N.A.
N.A.
57.8
43.4
40.5
N.A.
N.A.
N.A.
37
N.A.
N.A.
Protein Similarity:
100
97.7
94.4
83.7
N.A.
86.6
N.A.
N.A.
68.9
58.3
54.3
N.A.
N.A.
N.A.
55.3
N.A.
N.A.
P-Site Identity:
100
93.3
80
66.6
N.A.
60
N.A.
N.A.
20
13.3
0
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
93.3
86.6
73.3
N.A.
66.6
N.A.
N.A.
20
40
20
N.A.
N.A.
N.A.
0
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
0
0
0
0
12
0
0
0
12
12
12
0
% A
% Cys:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
0
0
0
0
0
12
0
0
12
56
0
0
% D
% Glu:
56
0
0
0
12
0
12
12
0
56
0
0
0
0
12
% E
% Phe:
0
0
23
0
0
0
0
0
0
12
0
12
0
12
0
% F
% Gly:
0
0
0
12
67
12
0
0
0
0
0
12
0
0
12
% G
% His:
0
0
0
0
0
0
0
0
0
12
0
0
12
0
0
% H
% Ile:
0
0
0
12
0
45
0
0
0
0
23
0
0
12
0
% I
% Lys:
0
0
12
0
0
0
0
12
12
0
23
0
0
0
0
% K
% Leu:
0
0
45
56
12
0
0
0
56
0
12
12
0
0
12
% L
% Met:
0
0
0
0
0
0
0
12
12
0
12
12
12
0
0
% M
% Asn:
0
45
0
0
0
0
0
23
0
0
0
0
0
0
0
% N
% Pro:
0
12
12
0
0
0
0
0
0
12
12
0
0
45
0
% P
% Gln:
0
12
0
0
0
12
0
0
0
0
0
0
0
0
0
% Q
% Arg:
12
12
0
12
0
12
0
0
0
0
12
0
0
0
0
% R
% Ser:
12
0
0
0
0
0
67
34
12
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
12
34
0
23
23
% T
% Val:
12
0
12
0
12
12
12
0
0
12
0
0
12
0
45
% V
% Trp:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
12
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _